A Functional Chemiluminescent Probe for in Vivo Imaging of Natural Killer Cell Activity Against Tumours

In vivo detection of natural killer (NK) cell activity against tumours was achieved with an activatable chemiluminescent probe containing a granzyme B-reactive peptide substrate linked to a phenoxydioxetane scaffold through a p-aminobenzyl alcohol linker. The rapid and specific chemiluminescence response of the probe was used to detect NK cell activity against breast cancer cells in living mice.