结合
化学
抗体-药物偶联物
肽
共轭体系
组合化学
抗体
生物结合
点击化学
药品
立体化学
单克隆抗体
生物化学
药理学
有机化学
免疫学
数学分析
生物
医学
聚合物
数学
作者
Tae-Jin Lee,Woo Jung Kim,Se Jeong Kwon,Sun Hee Park,Jin‐Young Kim,Hyo Jin Kang,Sang J. Chung
标识
DOI:10.1021/acs.orglett.0c03049
摘要
Antibody-drug conjugates (ADCs) in current clinical usage have been constructed via the nonspecific conjugation of drugs to antibodies, rendering the manufacturing processes difficult. In this study, a high-affinity IgG Fc-binding peptide equipped with a photoreactive amino acid was developed and successfully conjugated to Glu-382 of trastuzumab in a site-specific manner. The resulting conjugate was employed to generate a DAR 2 ADC product using click chemistry.
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