Colorimetric Detection Based on Localized Surface Plasmon Resonance for Determination of Chemicals in Urine

表面等离子共振 化学 纳米材料 纳米技术 生物传感器 胶体金 肉眼 纳米颗粒 比色法 银纳米粒子 生物分析 等离子体子 毒品检测 检出限 色谱法 材料科学 光电子学 生物化学
作者
Chutiparn Lertvachirapaiboon,Akira Baba,Kazunari Shinbo,Keizo Kato
出处
期刊:Analytical Sciences [Japan Society for Analytical Chemistry]
卷期号:37 (7): 929-940 被引量:2
标识
DOI:10.2116/analsci.20r005
摘要

Colorimetric sensors based on localized surface plasmon resonance (LSPR) have attracted much attention for biosensor and chemical sensor applications. The unique optical effect of LSPR is based on the nanostructure of noble metals (e.g., Au, Ag, and Al) and the refractive index of the environment surrounding these metal nanomaterials. When either the structure or the environment of these nanomaterials is changed, their optical properties change and can be observed by spectroscopic techniques or the naked eye. Colorimetric-probe-based LSPR provides a simple, rapid, real-time, nonlabelled, sensitive biochemical detection and can be used for point-of-care testing as well as rapid screening for the diagnosis of various diseases. Gold and silver nanoparticles, which are the two most widely used plasmonic nanomaterials, demonstrate strong and sensitive LSPR signals that can be used for the selective detection of several chemicals in biochemical compounds provided by the human body (e.g., urine and blood). This information can be used for the diagnosis of several human health conditions. This paper provides information regarding colorimetric probes based on LSPR for the detection of three major chemicals in human urine: creatinine, albumin, and glucose. In addition, the mechanisms of selective detection and quantitative analysis of these chemicals using metal nanoparticles are discussed along with colorimetric-detection-based LSPR for many other specific chemicals that can be detected in urine, such as catecholamine neurotransmitters, thymine, and various medicines. Furthermore, issues regarding the use of portable platforms for health monitoring with colorimetric detection based on LSPR are discussed.
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