丝素
丝绸
银纳米粒子
家蚕
生物相容性
丝胶
化学
极限抗拉强度
延伸率
生物高聚物
纳米颗粒
材料科学
纳米技术
食品科学
生物化学
复合材料
有机化学
聚合物
基因
作者
Yunhu Zhang,Meijuan Shi,Kai-Le Li,Rui Xing,Zhuo-Hua Chen,Xuedong Chen,Yongfeng Wang,Xiaofei Liu,Xinyin Liang,Yang‐Hu Sima,Shiqing Xu
标识
DOI:10.1080/09205063.2019.1692642
摘要
Biological modifications of the silk fibroin (silk) material have broad applications in textiles, biomedical materials and other industrial materials. It is economical to incorporate nanoparticles to the biosynthesis of silk fibroin by adding them to silkworm larval diets. This strategy may result in the rapid stable production of modified silk. Glucose-coated silver nanoparticles (AgNPs) were used to improve the AgNPs' biocompatibility, and the AgNPs were efficiently incorporated into silk by feeding. Larvae fed with AgNPs produced silk with significantly improved antibacterial properties and altered silk secondary structures. Both positive and negative effects on the growth and synthesis of silk proteins were observed after different AgNPs doses. Larvae feeding with low concentration of 0.02% and medium 0.20% AgNPs have greater transfer efficiencies of AgNPs to silk compared with feeding high concentration of 2.00% AgNPs. In addition, the elongation and tensile strength of the produced silk fibers were also significantly increased, with greater mammalian cell compatibility. The appropriate AgNPs concentration in the diet of silkworms can promote the synthesis of silk proteins, enhance their mechanical properties, improve their antibacterial property and inhibit the presence of Gram-negative bacteria.
科研通智能强力驱动
Strongly Powered by AbleSci AI