单加氧酶
生化工程
合成生物学
纳米技术
酶
生物技术
化学
计算生物学
生物
工程类
生物化学
细胞色素P450
材料科学
作者
Maximilian J. L. J. Fürst,Alejandro Gran‐Scheuch,Friso S. Aalbers,Marco W. Fraaije
出处
期刊:ACS Catalysis
日期:2019-10-25
卷期号:9 (12): 11207-11241
被引量:155
标识
DOI:10.1021/acscatal.9b03396
摘要
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their undisputable importance to society. Biotechnological advances hold the promise to enable a future of drastically reduced environmental impact and rigorously more efficient production routes at the same time. This is exemplified in the Baeyer–Villiger reaction, which offers a simple synthetic route to oxidize ketones to esters, but application is hampered by the requirement of hazardous and dangerous reagents. As an attractive alternative, flavin-containing Baeyer–Villiger monooxygenases (BVMOs) have been investigated for their potential as biocatalysts for a long time, and many variants have been characterized. After a general look at the state of biotechnology, we here summarize the literature on biochemical characterizations, mechanistic and structural investigations, as well as enzyme engineering efforts in BVMOs. With a focus on recent developments, we critically outline the advances toward tuning these enzymes suitable for industrial applications.
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