免疫系统
肿瘤微环境
癌症研究
巨噬细胞极化
癌症免疫疗法
重编程
表型
免疫疗法
生物
免疫学
细胞
基因
遗传学
生物化学
作者
Shuai Zong,Jinglei Li,Ziyang Ye,Xinmiao Zhang,Liu Yang,Xue Chen,Ming Ye
标识
DOI:10.1016/j.ijbiomac.2019.09.179
摘要
Therapeutic strategies that targeting tumor-associated macrophages (TAMs) reprogramming play a crucial role in ameliorating the immunosuppressive tumor microenvironment and boosting anti-tumor immune responses. In this study, we demonstrated that Lachnum polysaccharide (LEP) could work as an immunomodulator to reset TAMs from pro-tumor M2 to anti-tumor M1 phenotype. Mechanistically, LEP promoted Th1 polarization and the secretion of IFN-γ, which played a key role in M1 phenotype polarization. In parallel, LEP might directly activate M1 macrophages via TLR4 mediated NF-κB signaling pathway. Moreover, LEP also resulted in the accumulation of anti-tumor immune cells and decreased the infiltration of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) and Treg cells, thereby potentiating anti-tumor immunity. In summary, these results revealed a novel mechanism of the anti-tumor effect of LEP and provided a potential new avenue targeting TAMs and cancer immunotherapy.
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