米托蒽醌
药品
姜黄素
药物输送
体内
化学
药理学
抗药性
阿霉素
联合化疗
医学
化疗
材料科学
纳米技术
生物
外科
生物技术
微生物学
作者
Fangzhou Yu,Yalan Tu,Shi‐Wei Luo,Xuan Xiao,Yao Wang,Mingli Jiang,Xinqing Jiang,Ruimeng Yang,Youyong Yuan
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-02-26
卷期号:21 (5): 2216-2223
被引量:52
标识
DOI:10.1021/acs.nanolett.0c05028
摘要
The codelivery of drugs at specific optimal ratios to cancer cells is vital for combination chemotherapy. However, most of the current strategies are unable to coordinate the loading and release of drug combinations to acquire precise and controllable synergistic ratios. In this work, we designed an innovative dual-drug backboned and reduction-sensitive polyprodrug PEG-P(MTO-ss-CUR) containing the anticancer drugs mitoxantrone (MTO) and curcumin (CUR) at an optimal synergistic ratio to reverse drug resistance. Due to synchronous drug activation and polymer backbone degradation, drug release at the predefined ratio with a synergistic anticancer effect was demonstrated by in vitro and in vivo experiments. Therefore, the dual-drug delivery system developed in this work provides a novel and efficient strategy for combination chemotherapy.
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