血管通透性
受体酪氨酸激酶
蛋白质酪氨酸磷酸酶
细胞生物学
生物
血管生成
血管内皮生长抑制物
酪氨酸激酶
受体
酪氨酸
血管内皮生长因子A
磷酸化
血管内皮生长因子B
血管内皮生长因子
磷酸酶
癌症研究
信号转导
内分泌学
生物化学
血管内皮生长因子受体
出处
期刊:Physiology
[American Physiological Society]
日期:2021-03-01
卷期号:36 (2): 84-93
被引量:18
标识
DOI:10.1152/physiol.00026.2020
摘要
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is a receptor-type PTP (RPTP), predominantly expressed in vascular endothelial cells. It regulates embryonic and tumor angiogenesis and controls vascular permeability and homeostasis in inflammation. Major substrates are the tyrosine kinase receptor Tie-2 and the adhesion molecule VE-cadherin. This review describes how VE-PTP controls vascular functions by its various substrates and the therapeutic potential of VE-PTP in various pathophysiological settings.
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