An assessment of the functional effects of amphetamine-induced dendritic changes in the nucleus accumbens, medial prefrontal cortex, and hippocampus on different types of learning and memory function

伏隔核 神经科学 前额叶皮质 海马体 基底外侧杏仁核 安非他明 扁桃形结构 心理学 树突棘 神经可塑性 下托 认知 中枢神经系统 海马结构 多巴胺 齿状回
作者
Robert J. McDonald,Nancy S. Hong,Ammon Atwood,Amanda V. Tyndall,Bryan Kolb
出处
期刊:Neurobiology of Learning and Memory [Elsevier BV]
卷期号:180: 107408-107408 被引量:2
标识
DOI:10.1016/j.nlm.2021.107408
摘要

The present experiments investigated the effects of repeated amphetamine exposure on neural networks mediating different forms of learning and memory. Different components of these networks were assessed using various functional assays. The hypothesis was that abnormal dendritic changes in nucleus accumbens, medial prefrontal cortex, and hippocampus mediated by repeated amphetamine exposure would produce impairments on forms of learning and memory dependent on neural circuits relying on these brain systems, and have little or no effect on other forms of learning not dependent on these networks. Surprisingly, the results showed that many of the dendritic changes normally found in the nucleus accumbens, prefrontal cortex, and hippocampus following repeated amphetamine exposure were reversed back to control levels following extensive multi-domain cognitive training. Learning and memory functions associated with different neural networks also appeared normal except in one case. A neural network that includes, but is not limited to, the basolateral amygdala and nucleus accumbens was dysfunctional in rats repeatedly exposed to amphetamine despite the reversal of the majority of dendritic changes in the nucleus accumbens following cognitive training. Importantly, an increase in spine density that normally occurs in these brain regions following repeated amphetamine exposure remained following extensive cognitive training, particularly in the nucleus accumbens.
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