Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning

静电纺丝 纳米纤维 纳米- 材料科学 乙基纤维素 醋酸纤维素 聚合物 化学工程 纳米技术 高分子 纤维素 复合材料 化学 工程类 生物化学
作者
Chaokun Huang,Kerui Zhang,Qing Lin Gong,Deng‐Guang Yu,Jia Wang,Xiaoqin Tan,Heng Quan
出处
期刊:International Journal of Biological Macromolecules [Elsevier BV]
卷期号:152: 68-76 被引量:64
标识
DOI:10.1016/j.ijbiomac.2020.02.239
摘要

New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in which the shell section was a drug-polymer composite and the core section was a drug reservoir. With ethyl cellulose and ketoprofen as a filament-forming polymeric matrix and a model drug, respectively, a triaxial electrospinning apparatus was developed to conduct both coaxial and triaxial processes, by which monolithic nanofibers F1 and core-shell nano depots F2 were successfully prepared. Although both of them had the same double components, their different nanostructures generated considerable differences in providing drug sustained release profiles. The core-shell nanofiber depots F2 were able to provide a better zero-order drug release profile: no initial burst release, smooth sustained release effect, and smaller tailing-off release for a nice zero-order drug release kinetics. The release percentage (Q) can be linearly manipulated through the release time (t) according to the equation Q2 = 9.40 + 4.74 t (R = 0.9936), providing opportunity for precise administration. The developed strategy and advanced electrospinning technique exhibit a new way for constructing process-structure-performance relationships at nano scale and for expanding the potential applications of biological macromolecules in the applied fields.
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