Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning

静电纺丝 纳米纤维 纳米- 材料科学 乙基纤维素 醋酸纤维素 聚合物 化学工程 纳米技术 高分子 纤维素 复合材料 化学 工程类 生物化学
作者
Chaokun Huang,Kerui Zhang,Qing Lin Gong,Deng‐Guang Yu,Jia Wang,Xiaoqin Tan,Heng Quan
出处
期刊:International Journal of Biological Macromolecules [Elsevier BV]
卷期号:152: 68-76 被引量:64
标识
DOI:10.1016/j.ijbiomac.2020.02.239
摘要

New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in which the shell section was a drug-polymer composite and the core section was a drug reservoir. With ethyl cellulose and ketoprofen as a filament-forming polymeric matrix and a model drug, respectively, a triaxial electrospinning apparatus was developed to conduct both coaxial and triaxial processes, by which monolithic nanofibers F1 and core-shell nano depots F2 were successfully prepared. Although both of them had the same double components, their different nanostructures generated considerable differences in providing drug sustained release profiles. The core-shell nanofiber depots F2 were able to provide a better zero-order drug release profile: no initial burst release, smooth sustained release effect, and smaller tailing-off release for a nice zero-order drug release kinetics. The release percentage (Q) can be linearly manipulated through the release time (t) according to the equation Q2 = 9.40 + 4.74 t (R = 0.9936), providing opportunity for precise administration. The developed strategy and advanced electrospinning technique exhibit a new way for constructing process-structure-performance relationships at nano scale and for expanding the potential applications of biological macromolecules in the applied fields.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李爱国应助娜娜采纳,获得10
1秒前
1秒前
BingoTang发布了新的文献求助10
1秒前
淡淡蛋挞发布了新的文献求助10
2秒前
Huang_being发布了新的文献求助10
2秒前
2秒前
2秒前
可爱的函函应助sylnd126采纳,获得10
3秒前
pearsir发布了新的文献求助10
3秒前
爱学习的婷完成签到 ,获得积分10
3秒前
matthew完成签到,获得积分10
4秒前
4秒前
4秒前
沙亮完成签到 ,获得积分10
5秒前
Hello应助吵吵robot采纳,获得10
5秒前
weige发布了新的文献求助10
5秒前
共享精神应助城南徐师傅采纳,获得10
6秒前
proton发布了新的文献求助10
6秒前
CipherSage应助自信小笼包采纳,获得10
7秒前
大模型应助matthew采纳,获得10
8秒前
眉间一把刀完成签到,获得积分10
8秒前
8秒前
maomao发布了新的文献求助10
9秒前
9秒前
科研通AI2S应助naturehome采纳,获得10
11秒前
爆米花应助好宝宝采纳,获得10
12秒前
科研通AI2S应助Victoria采纳,获得10
12秒前
盛弟发布了新的文献求助10
13秒前
Myles发布了新的文献求助10
13秒前
研友_ZGAWYL完成签到,获得积分10
13秒前
14秒前
yookia应助烂漫的冰蓝采纳,获得10
16秒前
现代的东蒽完成签到,获得积分10
16秒前
16秒前
16秒前
上官若男应助幼汁汁鬼鬼采纳,获得10
16秒前
阿秋秋秋完成签到 ,获得积分10
17秒前
在水一方应助粥粥爱糊糊采纳,获得10
17秒前
19秒前
喻紫寒发布了新的文献求助10
19秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021