An abdominal phantom with anthropomorphic organ motion and multimodal imaging contrast for MR-guided radiotherapy

成像体模 呼吸 影像引导放射治疗 振膜(声学) 核医学 磁共振成像 医学 放射治疗 放射治疗计划 剂量学 膈式呼吸 生物医学工程 放射科 物理 解剖 声学 病理 替代医学 扬声器
作者
Artur Weidner,C. Stengl,Fabian Dinkel,S Dorsch,Carlos Murillo,Steffen Seeber,Regula Gnirs,A. Runz,Gernot Echner,Christian P. Karger,Oliver Jäkel
出处
期刊:Physics in Medicine and Biology [IOP Publishing]
卷期号:67 (4): 045009-045009 被引量:9
标识
DOI:10.1088/1361-6560/ac4ef8
摘要

Purpose. Improvements in image-guided radiotherapy (IGRT) enable accurate and precise treatment of moving tumors in the abdomen while simultaneously sparing healthy tissue. However, the lack of validation tools for newly developed MR-guided radiotherapy hybrid devices such as the MR-Linac is an open issue. This study presents a custom developed abdominal phantom with respiratory organ motion and multimodal imaging contrast to perform end-to-end tests for IGRT treatment planning scenarios.Methods. The abdominal phantom contains deformable and anatomically shaped liver and kidney models made of Ni-DTPA and KCl-doped agarose mixtures that can be reproducibly positioned within the phantom. Organ models are wrapped in foil to avoid ion exchange with the surrounding agarose and to provide stable T1 and T2 relaxation times as well as HU numbers. Breathing motion is realized by a diaphragm connected to an actuator that is hydraulically controlled via a programmable logic controller. With this system, artificial and patient-specific breathing patterns can be carried out. In 1.5 T magnetic resonance imaging (MRI), diaphragm, liver and kidney motion was measured and compared to the breathing motion of a healthy male volunteer for different breathing amplitudes including shallow, normal and deep breathing.Results. The constructed abdominal phantom demonstrated organ-equivalent intensity values in CT as well as in MRI. T1-weighted (T1w) and T2-weighted (T2w) relaxation times for 1.5 T and CT numbers were 552.9 ms, 48.2 ms and 48.8 HU (liver) as well as 950.42 ms, 79 ms and 28.2 HU (kidney), respectively. These values were stable for more than six months. Extracted breathing motion from a healthy volunteer revealed a liver to diaphragm motion ratio (LDMR) of 64.4% and a kidney to diaphragm motion ratio (KDMR) of 30.7%. Well-comparable values were obtained for the phantom (LDMR: 65.5%, KDMR: 27.5%).Conclusions. The abdominal phantom demonstrated anthropomorphic T1 and T2 relaxation times as well as HU numbers and physiological motion pattern in MRI and CT. This allows for wide use in the validation of IGRT including MRgRT.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
葫芦娃完成签到,获得积分10
刚刚
Jasper应助iShine采纳,获得10
刚刚
lelele发布了新的文献求助10
1秒前
1秒前
2秒前
dongdoctor完成签到 ,获得积分10
2秒前
魏莱发布了新的文献求助10
2秒前
Ulrica完成签到,获得积分10
2秒前
CipherSage应助包容追命采纳,获得10
2秒前
owldan完成签到 ,获得积分10
4秒前
一直向前完成签到,获得积分10
4秒前
舒服的映安完成签到 ,获得积分10
4秒前
lmh011115发布了新的文献求助10
5秒前
6秒前
一直向前发布了新的文献求助10
6秒前
End完成签到 ,获得积分10
7秒前
沉静的红酒完成签到,获得积分10
8秒前
yzxzdm完成签到 ,获得积分10
8秒前
Yara.H完成签到 ,获得积分10
8秒前
Meng完成签到,获得积分10
9秒前
11秒前
量子星尘发布了新的文献求助10
13秒前
包容追命发布了新的文献求助10
15秒前
15秒前
梦鱼完成签到,获得积分10
16秒前
小林不熬夜完成签到,获得积分10
16秒前
玛卡巴卡完成签到,获得积分10
17秒前
希尔伯特发布了新的文献求助10
19秒前
Jasper应助dailyyang采纳,获得10
19秒前
冬凌草完成签到 ,获得积分10
19秒前
阿若完成签到,获得积分10
19秒前
英姑应助单纯冰棍采纳,获得10
19秒前
高高从霜完成签到 ,获得积分10
20秒前
lmh011115完成签到,获得积分10
20秒前
包容追命完成签到,获得积分20
21秒前
zhenya完成签到,获得积分10
22秒前
xiang929完成签到 ,获得积分10
24秒前
小文子完成签到,获得积分10
24秒前
Mae完成签到 ,获得积分10
25秒前
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038446
求助须知:如何正确求助?哪些是违规求助? 3576149
关于积分的说明 11374627
捐赠科研通 3305875
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892680
科研通“疑难数据库(出版商)”最低求助积分说明 815048