内德4
泛素连接酶
泛素
细胞生物学
生物
蛋白质稳态
化学
蛋白酶体
作者
Daria Sicari,Janine Weber,Elena Maspero,Simona Polo
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2022-02-07
摘要
Due to its fundamental role in all eukaryotic cells, a deeper understanding of the molecular mechanisms underlying ubiquitination is of central importance. Being responsible for chain specificity and substrate recognition, E3 ligases are the selective elements of the ubiquitination process. In this review, we discuss different cellular pathways regulated by one of the first identified E3 ligase, NEDD4, focusing on its pathophysiological role, its known targets and modulators. In addition, we highlight small molecule inhibitors that act on NEDD4 and discuss new strategies to effectively target this E3 enzyme.
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