纤维化
安普克
舒张期
内科学
内分泌学
医学
心脏纤维化
心肌纤维化
表型
前胶原肽酶
生物
细胞生物学
蛋白激酶A
磷酸化
血压
基因
生物化学
作者
Aude Angelini,Jesus Ortiz-Urbina,JoAnn Trial,Anilkumar K. Reddy,Anna Malovannaya,Antrix Jain,Mark L. Entman,George E. Taffet,Katarzyna A. Cieslik
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2022-06-17
卷期号:323 (2): H285-H300
被引量:1
标识
DOI:10.1152/ajpheart.00078.2022
摘要
The aging heart develops diastolic dysfunction because of increased collagen deposition. We attempted to reduce collagen expression in the old heart by activating AMPK using AICAR. An improvement of diastolic function and reduction of cardiac fibrosis was found only in the female heart and correlated with decreased procollagen expression and increased degradation of the transcription factor Gli1. Male hearts display blunted AICAR-dependent AMPK activation and therefore this treatment had no benefits for the male mice.
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