卵清蛋白
生物相容性
化学
壳聚糖
两亲性
药物输送
纳米颗粒
多糖
生物化学
纳米技术
有机化学
材料科学
共聚物
免疫系统
聚合物
生物
免疫学
作者
Lihua Li,Xinyu Sun,Hui Zhang,Mengna Dong,Jiao Wang,Shuang Zhao,Minghui Shang,Xin Wang,Hui Zhangsun,Li Wang
标识
DOI:10.1016/j.carbpol.2022.119779
摘要
Nano-delivery systems play an important role in the development of nutritional supplements due to their efficient encapsulation and delivery properties for nutrients. Herein, we prepared protein-polysaccharide nanoparticles as a novel amphiphilic nano-delivery system based on gallic acid modified chitosan (GCS) and ovalbumin (OVA) by pH-driven and calcium ion crosslinking. The nanoparticles loaded with hydrophilic riboflavin (Rib) and hydrophobic quercetin (Que) as nutrient models were abbreviated as GCS-OVA-Rib NPs and GCS-OVA-Que NPs, respectively. Their encapsulation efficiencies for Rib and Que. were 66.36 % and 96.61 %, respectively. In addition, GCS-OVA-Rib NPs and GCS-OVA-Que NPs showed antioxidant activity as well as good stability and delivery capacity for Rib and Que. in simulated digestion with release ratios of 78.38 % and 84.15 %, respectively. More importantly, GCS-OVA-Rib/Que. NPs performed good biocompatibility for further applications. Overall, this work provides some useful insights for the design of novel amphiphilic nano-delivery systems based on polysaccharides and proteins.
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