纳米颗粒
介孔二氧化硅
姜黄素
纳米结构
介孔材料
化学工程
材料科学
纳米医学
纳米技术
化学
有机化学
催化作用
生物化学
工程类
作者
A. Nitthin Ananth,V. Nagarajan,Sanjeev Kumar,P. Sasikumar,Giuseppe Chirico,Laura D’Alfonso,Sujin P. Jose
标识
DOI:10.1002/ppsc.202200062
摘要
Abstract The main goal of this study is to develop methods for the simultaneous synthesis and loading of curcumin nanoparticles onto mesoporous silica by a sequential solvent evaporation approach. It is known that the presence of cosolvents and surfactants facilitates the homogenous formation of colloidal curcumin nanoparticles and enhances loading into mesoporous silica nanoparticles. The stability of the curcumin nanoparticles and their substantial loading are characterized as a function of the mesoporous silica nanostructures (MSN) surface properties, allowing to put into evidence how the dielectric nanoenvironment, largely determined by the water dynamics in the presence of cosolvents and of surfactants, plays a crucial role in the micelle mediated loading of curcumin nanoparticles into the mesoporous silica nanostructure. The interfacial hydrogen bonded corrugated network with its occupational electronic distribution shields the curcumin nanoparticles loaded onto the MSNs. Highly monodispersed nanostructures that are obtained that exhibit redox behavior, Fickian diffusion following linear compensation effect, and increased ionic activity triggered in an acidic pH ambiance. The augmented bioactivity of the human acute monocyte leukemia cancer cell line U937 elects the synthesized curcumin nanoparticles @ MSNs as a suitable nanostructure against acidic tumor microenvironment.
科研通智能强力驱动
Strongly Powered by AbleSci AI