Photothermal-Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon–Bone Healing

脚手架 肌腱 生物医学工程 材料科学 热情 纳米纤维 骨愈合 肩袖 解剖 纳米技术 医学
作者
Cheng‐Hao Yu,Tianrui Wang,Hongcui Diao,Na Liu,Yi Zhang,Hongyuan Jiang,Peng Zhao,Zhengyi Shan,Zewen Sun,Tong Wu,Xiumei Mo,Tengbo Yu
出处
期刊:Advanced Fiber Materials [Springer Nature]
卷期号:4 (4): 908-922 被引量:19
标识
DOI:10.1007/s42765-022-00154-7
摘要

Scaffolds functionalized with graded changes in both fiber alignment and mineral content are more appealing for tendon-bone healing. This study reports the healing of rotator cuff injury using a heterogeneous nanofiber scaffold, which is associated with a structural gradating from aligned to random and an increasing gradient of mineral content in the same orientation. The photothermal-triggered structural change of a nanofiber scaffold followed by graded mineralization is key to constructing such scaffolds. This type of scaffold was found to be biocompatible and provide beneficial contact guidance in the manipulation of tendon-derived stem cell morphologies in vitro. Specifically, tenogenic and osteogenic differentiation of tendon-derived stem cells were simultaneously achieved using the fabricated scaffold. In vivo investigation also showed the improved healing of rabbit rotator cuff injuries based on immunohistochemical analysis and biomechanical investigation that indicates the promising potential of a dual-gradient nanofiber scaffold in clinical tendon-bone healing.Graphical abstractDual-gradient nanofiber scaffold with transitions in both surface structure and mineral content was designed and manufactured to replicate the native interface between tendon and bone to facilitate the tendon-bone healing in a rabbit rotator cuff injury model.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
4秒前
Vincent完成签到 ,获得积分10
4秒前
4秒前
恐龙完成签到 ,获得积分10
5秒前
mei完成签到,获得积分10
6秒前
默默的井完成签到,获得积分10
7秒前
8秒前
乐观寻绿完成签到 ,获得积分10
8秒前
coolkid完成签到 ,获得积分10
8秒前
美味cookies发布了新的文献求助10
8秒前
8秒前
灵巧的从寒发布了新的文献求助100
8秒前
tuanheqi应助spk采纳,获得150
9秒前
11秒前
loulan发布了新的文献求助10
15秒前
瑾玉发布了新的文献求助10
16秒前
coconut完成签到,获得积分10
16秒前
brave heart完成签到,获得积分10
17秒前
自然的晓山完成签到,获得积分10
18秒前
Raymond完成签到,获得积分0
19秒前
共享精神应助songf11采纳,获得30
20秒前
香蕉觅云应助loulan采纳,获得30
20秒前
小蘑菇应助自然的晓山采纳,获得10
22秒前
kinase完成签到 ,获得积分10
23秒前
上好佳完成签到,获得积分10
23秒前
Glngar完成签到,获得积分10
24秒前
JamesPei应助老王很烦恼采纳,获得10
24秒前
mei发布了新的文献求助10
28秒前
click完成签到 ,获得积分10
28秒前
JMrider完成签到,获得积分10
31秒前
33秒前
saberLee完成签到 ,获得积分10
33秒前
34秒前
Dandelion完成签到,获得积分10
34秒前
35秒前
37秒前
37秒前
40秒前
暴躁的傲松完成签到 ,获得积分10
43秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3151906
求助须知:如何正确求助?哪些是违规求助? 2803220
关于积分的说明 7852502
捐赠科研通 2460587
什么是DOI,文献DOI怎么找? 1309912
科研通“疑难数据库(出版商)”最低求助积分说明 629066
版权声明 601760