A nationwide prospective clinical trial on active surveillance in patients with non-intra-abdominal desmoid-type fibromatosis; the Grafiti trial

Background: Desmoid-type fibromatosis (DTF) has a highly variable clinical course, displaying phases of progressive growth, stabilization or even spontaneous regression without treatment. Active surveillance (AS) is currently recommended as primary treatment. The aim of this study was to assess tumour behaviour and the efficacy of AS in DTF patients.