生物
RNA聚合酶Ⅱ
RNA剪接
拟南芥
内含子
遗传学
葛兰素史克-3
选择性拼接
抄写(语言学)
基因
转录因子
染色质
拼接因子
细胞生物学
激酶
核糖核酸
基因表达
外显子
发起人
哲学
突变体
语言学
作者
Chengxiang Li,Bin Chen,Hao Yu
出处
期刊:The Plant Cell
[Oxford University Press]
日期:2022-01-01
卷期号:34 (7): 2730-2746
被引量:1
标识
DOI:10.1093/plcell/koac110
摘要
Abstract Glycogen synthase kinase 3 (GSK3) family members serve as signaling hubs for plant development and stress responses, yet the underlying mechanism of their transcriptional regulation remains a long-standing mystery. Here we show that the transcription of SHAGGY-like kinase 11/12 (SK11/12), two members of the GSK3 gene family, is promoted by the splicing factor SmD1b, which is essential for distributing carbon sources into storage and protective components in Arabidopsis seeds. The chromatin recruitment of SmD1b at the SK11/12 loci promotes their transcription associated with co-transcriptional splicing of the first introns in the 5′-untranslated region of SK11/12. The loss of SmD1b function generates transcripts with unspliced introns that create disruptive R-loops to hamper the transcriptional elongation of SK11/12, in addition to compromising the recruitment of RNA polymerase II to the SK11/12 genomic regions. These effects imposed by SmD1b determine the transcription of SK11/12 to confer a key switch of carbon flow among metabolic pathways in zygotic and maternal tissues in seeds.
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