克拉斯
结直肠癌
药品
癌症研究
突变
癌症
医学
生物
药理学
内科学
遗传学
基因
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2020-10-28
卷期号:10 (12): OF2-OF2
被引量:10
标识
DOI:10.1158/2159-8290.cd-nb2020-098
摘要
Abstract According to the KRYSTAL-1 study, the KRASG12c inhibitor adagrasib, also known as MRTX849, is largely well tolerated and shows considerable efficacy in patients with non–small cell lung cancer harboring this mutation. The drug is also active, albeit more modestly, in colorectal cancer and several other solid tumor types.
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