血管生成
微泡
外体
医学
小RNA
伤口愈合
糖尿病足
糖尿病
生物信息学
癌症研究
药理学
外科
生物
内分泌学
生物化学
基因
作者
Ruohan Lou,Jiali Chen,Zhou Fei,Chunming Wang,Chung‐Hang Leung,Ligen Lin
标识
DOI:10.1016/j.drudis.2022.07.008
摘要
Diabetic foot ulcers are one of the most common complications of diabetes, requiring repeated surgical intervention and leading to amputation. Owing to the lack of effective drugs, novel therapeutics need to be explored. Decreased angiogenic factors, endothelial cell dysfunction and vascular lumen stenosis impair angiogenesis in diabetic wounds. Exosome-cargoed microRNAs are emerging as pivotal regulators of angiogenesis during wound closure. Herein, we summarize the up-to-date knowledge of exosomal microRNAs in modulating angiogenesis and accelerating diabetic wound healing, as well as their targets and underlying mechanisms. Exosomal microRNAs could be therapeutics with negligible rejection complications and good compatibility to treat diabetic foot ulcers.
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