Visible Light‐induced Decarboxylative Alkylations Enabled by Electron Donor‐Acceptor Complex

Abstract We demonstrated herein a versatile protocol for visible‐light‐induced decarboxylative alkylations enabled by electron‐donor acceptor complex. An array of primary, secondary, tertiary and amino acid‐derived redox‐active esters (RAEs) were all amenable substrates to undergo radical decarboxylation to be coupled with a diverse range of nucleophiles, creating diverse C(sp 3 )−C(sp 3 ) and C(sp 3 )−C(sp 2 ) bonds with high efficiency. It is worth noting that Katritzky's salt and Togni's reagent were also suitable substrates, affording deaminative alkylation and trifluoromethylation products in high yields. Additionally, a one‐pot two‐step telescoped procedure and continuous‐flow process further increase the synthetic utility of this catalytic system.