纳米医学
乙二醇
纳米生物技术
化学
PEG比率
纳米颗粒
聚合物
蛋白质吸附
生物物理学
材料科学
表面改性
纳米技术
有机化学
物理化学
经济
生物
财务
作者
Wen Yang,Lin Wang,Mulin Fang,Vinit Sheth,Yushan Zhang,Alyssa Holden,Nathan D. Donahue,Dixy E. Green,Alex N. Frickenstein,Evan M. Mettenbrink,Tyler A. Schwemley,Emmy R. Francek,Majood Haddad,Md. Nazir Hossen,Shirsha Mukherjee,Si Wu,Paul L. DeAngelis,Stefan Wilhelm
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-02-15
卷期号:22 (5): 2103-2111
被引量:32
标识
DOI:10.1021/acs.nanolett.2c00349
摘要
Nanoparticle modification with poly(ethylene glycol) (PEG) is a widely used surface engineering strategy in nanomedicine. However, since the artificial PEG polymer may adversely impact nanomedicine safety and efficacy, alternative surface modifications are needed. Here, we explored the "self" polysaccharide heparosan (HEP) to prepare colloidally stable HEP-coated nanoparticles, including gold and silver nanoparticles and liposomes. We found that the HEP-coating reduced the nanoparticle protein corona formation as efficiently as PEG coatings upon serum incubation. Liquid chromatography–mass spectrometry revealed the protein corona profiles. Heparosan-coated nanoparticles exhibited up to 230-fold higher uptake in certain innate immune cells, but not in other tested cell types, than PEGylated nanoparticles. No noticeable cytotoxicity was observed. Serum proteins did not mediate the high cell uptake of HEP-coated nanoparticles. Our work suggests that HEP polymers may be an effective surface modification technology for nanomedicines to safely and efficiently target certain innate immune cells.
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