D-二聚体
医学
纤维蛋白原
乳胶固色试验
内科学
胃肠病学
免疫学
抗体
作者
Abhishek Pathak,Varun Kumar Singh,Anand Kumar,Vijaya Nath Mishra,Deepika Joshi,Rameshwar Nath Chaurasia
标识
DOI:10.1177/09727531211063138
摘要
Cerebral venous sinus thrombosis (CVST) is an uncommon subtype of stroke, and the role of D-dimer and fibrinogen in early diagnosis of CVST has been studied with varying results. The present study aims to study the role of the combination of D-dimer and fibrinogen in early diagnosis of acute CVST.Forty consecutive confirmed acute CVST cases admitted at a tertiary care center were recruited for the study. D-dimer and fibrinogen were assessed by a rapid semiquantitative latex agglutination assay.Out of the 40 CVST patients, 21 (52.50%) were females. The mean age of the patients was 37.58 years ± 19.17 years. Common clinical features were headache (N = 38 [95%]), papilloedema (N = 15 [37.5%]), and seizures (N = 12 [30%]). Although the sensitivity (75%) of the combination of D-dimer and fibrinogen assay was lower than that of D-dimer or fibrinogen alone, the specificity and positive predictive value (75% each) was higher.The combination of D-dimer and fibrinogen testing may aid in an early diagnosis of acute CVST and in better management.
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