Association of metabolic dysfunction-associated fatty liver disease with kidney disease

医学 脂肪肝 脂肪变性 代谢综合征 肾脏疾病 糖尿病 2型糖尿病 疾病 内科学 肝活检 2型糖尿病 胃肠病学
作者
Ting-Yao Wang,Rui-Fang Wang,Zhi-Ying Bu,Giovanni Targher,Christopher D. Byrne,Dan-Qin Sun,Ming-Hua Zheng
出处
期刊:Nature Reviews Nephrology [Springer Nature]
被引量:1
标识
DOI:10.1038/s41581-021-00519-y
摘要

Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more than 5% of hepatocytes in the absence of excessive alcohol consumption and other secondary causes of hepatic steatosis. In 2020, the more inclusive term metabolic (dysfunction)-associated fatty liver disease (MAFLD) — defined by broader diagnostic criteria — was proposed to replace the term NAFLD. The new terminology and revised definition better emphasize the pathogenic role of metabolic dysfunction and uses a set of definitive, inclusive criteria for diagnosis. Diagnosis of MAFLD is based on evidence of hepatic steatosis (as assessed by liver biopsy, imaging techniques or blood biomarkers and scores) in persons who are overweight or obese and have type 2 diabetes mellitus or metabolic dysregulation, regardless of the coexistence of other liver diseases or excessive alcohol consumption. The known association between NAFLD and chronic kidney disease (CKD) and our understanding that CKD can occur as a consequence of metabolic dysfunction suggests that individuals with MAFLD — who by definition have fatty liver and metabolic comorbidities — are at increased risk of CKD. In this Perspective article, we discuss the clinical associations between MAFLD and CKD, the pathophysiological mechanisms by which MAFLD may increase the risk of CKD and the potential drug treatments that may benefit both conditions.
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