苯硼酸
化学
铃木反应
硝基苯
催化作用
偶联反应
钯
组合化学
有机化学
作者
Vijayaragavan Elumalai,Alexander H. Sandtorv,Hans‐René Bjørsvik
标识
DOI:10.1002/ejoc.201501487
摘要
Abstract A simple and efficient method for Suzuki cross‐coupling of highly substituted and congested 1‐chloro‐2‐nitrobenzene with phenylboronic acid was developed, investigated, and optimized. The reaction conditions comprises a mixture of MeOH and water (4:1) as the reaction medium, readily available and cheap Pd(PPh 3 ) 4 as catalyst, sodium carbonate as base, and microwave heating, which affords a fast reaction rate with good outcomes. The procedure was proven to have high functional group tolerance with phenylboronic acid and for 1‐chloro‐2‐nitrobenzene and thus is a general method for the synthesis of 2‐nitrobiphenyl. The target scaffold, 2‐nitrobiphenyls, was produced in excellent yields with excellent selectivities in all cases.
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