心脏毒性
医学
疾病
癌症
恶性肿瘤
重症监护医学
放射治疗
肿瘤科
内科学
化疗
生物信息学
生物
作者
Carrie Geisberg Lenneman,Douglas B. Sawyer
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2016-03-18
卷期号:118 (6): 1008-1020
被引量:270
标识
DOI:10.1161/circresaha.115.303633
摘要
Through the success of basic and disease-specific research, cancer survivors are one of the largest growing subsets of individuals accessing the healthcare system. Interestingly, cardiovascular disease is the second leading cause of morbidity and mortality in cancer survivors after recurrent malignancy. This recognition has helped stimulate a collaboration between oncology and cardiology practitioners and researchers, and the portmanteau cardio-oncology (also known as onco-cardiology) can now be found in many medical centers. This collaboration promises new insights into how cancer therapies impact cardiovascular homeostasis and long-term effects on cancer survivors. In this review, we will discuss the most recent views on the cardiotoxicity related to various classes of chemotherapy agents and radiation. We will also discuss broadly the current strategies for treating and preventing cardiovascular effects of cancer therapy.
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