髓鞘
中枢神经系统
胆固醇
神经系统
外周神经系统
神经科学
生物
医学
内分泌学
作者
G. Jackson Snipes,Ueli Suter
出处
期刊:Sub-cellular biochemistry
日期:1997-01-01
卷期号:: 173-204
被引量:63
标识
DOI:10.1007/978-1-4615-5901-6_7
摘要
Although it is well known that the central nervous system (CNS) and the peripheral nervous system (PNS), and in particular their myelin, contain large quantities of cholesterol, the specific role of this lipid in the structure and function of the nervous system remains elusive. In this review, we will summarize progress in our understanding of the role of cholesterol in the CNS and PNS with a particular emphasis on myelin. In the first part, we will provide an overview of the role of cholesterol in the biochemical composition and the structure of myelin, followed by a summary of the current knowledge of the biosynthesis and metabolism of cholesterol within neural tissues. Finally, we will review the association of cholesterol with various pathologies affecting the nervous system, including Alzheimer’s disease, tellurium toxicity, and the Smith—Lemli—Opitz syndrome.
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