受体
细胞生物学
生物
5-HT2受体
5-羟色胺受体
视紫红质样受体
激酶
G蛋白偶联受体
受体酪氨酸激酶
神经科学
血清素
信号转导
代谢受体
生物化学
兴奋剂
作者
Bryan L. Roth,Susan A. Berry,Wesley K. Kroeze,David L. Willins,Kurt Kristiansen
出处
期刊:Critical Reviews in Neurobiology
[Begell House Inc.]
日期:1998-01-01
卷期号:12 (4): 319-338
被引量:109
标识
DOI:10.1615/critrevneurobiol.v12.i4.30
摘要
Serotonin 5-HT2A receptors are essential for a large number of physiological functions in the central nervous system and periphery. This review article summarizes our current knowledge of the molecular biology and mechanisms of regulation of 5-HT2A receptors. The mode of drug binding using data derived from molecular modeling and site-directed mutagenesis is described. The cellular and subcellular localization of 5-HT2A receptors is described, and the concentration of 5-HT2A receptors on apical dendrites of pyramidal neurons is emphasized. Various modes of regulation of 5-HT2A receptors are also summarized, including transcriptional, post-translational and mRNA editing processes. Finally, an integrated model of 5-HT2A receptor regulation that involves various protein kinases (protein kinase C, G-protein receptor kinases), arrestins, clathrin-coated vesicles, endosomes and lysosomes. The relevance of these pathways for antidepressant and antipsychotic drug actions is emphasized.
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