Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction

胎儿 极低密度脂蛋白 胆固醇 内分泌学 内科学 脂类学 脂蛋白 代谢组学 宫内生长受限 脂质代谢 新陈代谢 生物 胎儿生长 化学 生物化学 怀孕 医学 生物信息学 遗传学
作者
Jezid Miranda,Rui V. Simões,Cristina Paulés,Daniel Cañueto,Miguel Ángel Pardo-Cea,Maria Luisa García‐Martín,F. Crovetto,Rocío Fuertes-Martín,Mónica Doménech,María Dolores Gómez‐Roig,E. Eixarch,Ramón Estruch,Stefan R. Hansson,Núria Amigó,Nicolau Cañellas,F. Crispi,E. Gratacós
出处
期刊:Scientific Reports [Springer Nature]
卷期号:8 (1) 被引量:47
标识
DOI:10.1038/s41598-018-31832-5
摘要

Abstract Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wangch198201发布了新的文献求助10
1秒前
章鱼完成签到 ,获得积分10
2秒前
共享精神应助Scarlett采纳,获得10
3秒前
露亮发布了新的文献求助10
3秒前
7秒前
诗瑜完成签到,获得积分10
8秒前
婷安wst完成签到,获得积分20
9秒前
13秒前
希望天下0贩的0应助pulga采纳,获得10
13秒前
聪明豁发布了新的文献求助10
13秒前
16秒前
18秒前
CipherSage应助很厉害的黄桃采纳,获得10
18秒前
Atopos发布了新的文献求助10
18秒前
SciGPT应助lili采纳,获得10
19秒前
wangmengcheng完成签到,获得积分10
20秒前
xx应助卢敏明采纳,获得10
22秒前
wangmengcheng发布了新的文献求助10
22秒前
兰亭序发布了新的文献求助10
23秒前
李健的小迷弟应助聪明豁采纳,获得10
23秒前
单薄广山发布了新的文献求助10
25秒前
lrh4完成签到,获得积分10
28秒前
漂洋过海应助carbon-dots采纳,获得10
29秒前
29秒前
Garry应助拉长的凌旋采纳,获得10
30秒前
31秒前
32秒前
34秒前
坚若磐石完成签到,获得积分10
35秒前
滕皓轩发布了新的文献求助10
35秒前
Scarlett发布了新的文献求助10
35秒前
xql关注了科研通微信公众号
37秒前
科研通AI2S应助Atopos采纳,获得10
40秒前
40秒前
BK2008发布了新的文献求助10
40秒前
沉静的乘风完成签到,获得积分10
41秒前
43秒前
拉长的凌旋完成签到,获得积分10
43秒前
zhangpeipei完成签到,获得积分10
47秒前
47秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189052
求助须知:如何正确求助?哪些是违规求助? 2838497
关于积分的说明 8019989
捐赠科研通 2501333
什么是DOI,文献DOI怎么找? 1335547
科研通“疑难数据库(出版商)”最低求助积分说明 637595
邀请新用户注册赠送积分活动 605656