Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction

胎儿 极低密度脂蛋白 胆固醇 内分泌学 内科学 脂类学 脂蛋白 代谢组学 宫内生长受限 脂质代谢 新陈代谢 生物 胎儿生长 化学 生物化学 怀孕 医学 生物信息学 遗传学
作者
Jezid Miranda,Rui V. Simões,Cristina Paulés,Daniel Cañueto,Miguel Ángel Pardo-Cea,Maria Luisa García‐Martín,F. Crovetto,Rocío Fuertes-Martín,Mónica Doménech,María Dolores Gómez‐Roig,E. Eixarch,Ramón Estruch,Stefan R. Hansson,Núria Amigó,Nicolau Cañellas,F. Crispi,E. Gratacós
出处
期刊:Scientific Reports [Springer Nature]
卷期号:8 (1) 被引量:47
标识
DOI:10.1038/s41598-018-31832-5
摘要

Abstract Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
Tao完成签到,获得积分10
6秒前
6秒前
斯文败类应助耶斯耶斯采纳,获得10
7秒前
7秒前
李健应助岚12采纳,获得10
8秒前
俞若枫完成签到,获得积分10
10秒前
raymond完成签到,获得积分10
11秒前
15秒前
wanghao完成签到 ,获得积分10
16秒前
神凰完成签到,获得积分10
17秒前
顾矜应助知识四面八方来采纳,获得10
20秒前
胖豆儿完成签到 ,获得积分10
22秒前
郭泓嵩完成签到,获得积分10
23秒前
研友_VZG7GZ应助科研通管家采纳,获得10
23秒前
科目三应助科研通管家采纳,获得10
24秒前
ding应助科研通管家采纳,获得10
24秒前
gnr2000应助科研通管家采纳,获得10
24秒前
酷波er应助科研通管家采纳,获得10
24秒前
不配.应助科研通管家采纳,获得10
24秒前
CodeCraft应助科研通管家采纳,获得10
24秒前
bkagyin应助科研通管家采纳,获得30
24秒前
24秒前
24秒前
李健的小迷弟应助盼盼527采纳,获得10
28秒前
28秒前
劲秉应助复杂的保温杯采纳,获得10
29秒前
MoLuan发布了新的文献求助10
31秒前
jiegelaile完成签到,获得积分10
31秒前
之之芝士完成签到,获得积分10
32秒前
33秒前
34秒前
别偷我增肌粉完成签到,获得积分20
36秒前
紫津完成签到 ,获得积分10
36秒前
37秒前
悄悄是心上的肖肖完成签到 ,获得积分10
37秒前
lkfiean完成签到,获得积分10
38秒前
YangSY完成签到,获得积分10
39秒前
Ning完成签到,获得积分10
41秒前
43秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3187770
求助须知:如何正确求助?哪些是违规求助? 2837517
关于积分的说明 8015287
捐赠科研通 2500112
什么是DOI,文献DOI怎么找? 1334764
科研通“疑难数据库(出版商)”最低求助积分说明 637295
邀请新用户注册赠送积分活动 605251