清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction

胎儿 极低密度脂蛋白 胆固醇 内分泌学 内科学 脂类学 脂蛋白 代谢组学 宫内生长受限 脂质代谢 新陈代谢 生物 胎儿生长 化学 生物化学 怀孕 医学 生物信息学 遗传学
作者
Jezid Miranda,Rui V. Simões,Cristina Paulés,Daniel Cañueto,Miguel Ángel Pardo-Cea,Maria Luisa García‐Martín,F. Crovetto,Rocío Fuertes-Martín,Mónica Doménech,María Dolores Gómez‐Roig,E. Eixarch,Ramón Estruch,Stefan R. Hansson,Núria Amigó,Nicolau Cañellas,F. Crispi,E. Gratacós
出处
期刊:Scientific Reports [Springer Nature]
卷期号:8 (1) 被引量:47
标识
DOI:10.1038/s41598-018-31832-5
摘要

Abstract Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
8秒前
Kapur完成签到,获得积分10
9秒前
颜陌完成签到,获得积分10
11秒前
海派Hi完成签到 ,获得积分10
13秒前
19秒前
33秒前
44秒前
47秒前
Haydeehu完成签到,获得积分10
49秒前
53秒前
英俊的铭应助加贝采纳,获得30
55秒前
59秒前
1分钟前
简择两发布了新的文献求助10
1分钟前
方白秋完成签到,获得积分10
1分钟前
JackWang发布了新的文献求助10
1分钟前
1分钟前
Krim完成签到 ,获得积分10
2分钟前
2分钟前
may发布了新的文献求助10
2分钟前
星辰大海应助may采纳,获得50
2分钟前
五二五四完成签到,获得积分10
2分钟前
在水一方应助简择两采纳,获得10
3分钟前
传奇3应助jiacheng采纳,获得20
3分钟前
cnbhhhhh发布了新的文献求助10
3分钟前
4分钟前
4分钟前
今后应助科研通管家采纳,获得10
4分钟前
4分钟前
4分钟前
4分钟前
5分钟前
5分钟前
5分钟前
5分钟前
JueruiWang1258完成签到,获得积分10
5分钟前
yurbb完成签到,获得积分10
5分钟前
5分钟前
6分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200773
求助须知:如何正确求助?哪些是违规求助? 2850531
关于积分的说明 8072235
捐赠科研通 2514267
什么是DOI,文献DOI怎么找? 1347000
科研通“疑难数据库(出版商)”最低求助积分说明 640305
邀请新用户注册赠送积分活动 610502