Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction

胎儿 极低密度脂蛋白 胆固醇 内分泌学 内科学 脂类学 脂蛋白 代谢组学 宫内生长受限 脂质代谢 新陈代谢 生物 胎儿生长 化学 生物化学 怀孕 医学 生物信息学 遗传学
作者
Jezid Miranda,Rui V. Simões,Cristina Paulés,Daniel Cañueto,Miguel Ángel Pardo-Cea,Maria Luisa García‐Martín,F. Crovetto,Rocío Fuertes-Martín,Mónica Doménech,María Dolores Gómez‐Roig,E. Eixarch,Ramón Estruch,Stefan R. Hansson,Núria Amigó,Nicolau Cañellas,F. Crispi,E. Gratacós
出处
期刊:Scientific Reports [Springer Nature]
卷期号:8 (1) 被引量:47
标识
DOI:10.1038/s41598-018-31832-5
摘要

Abstract Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
情怀应助ABS采纳,获得10
1秒前
快乐科研完成签到,获得积分20
2秒前
3秒前
3秒前
wyy应助ckzsj采纳,获得30
5秒前
8秒前
我是老大应助快乐科研采纳,获得10
8秒前
坦率续完成签到,获得积分10
9秒前
浮流少年完成签到,获得积分10
11秒前
13秒前
14秒前
傻傻的哈密瓜完成签到,获得积分10
15秒前
王小黑发布了新的文献求助10
15秒前
15秒前
Josh应助霸气凡白采纳,获得10
15秒前
丘比特应助AptRank采纳,获得20
16秒前
超级冰薇发布了新的文献求助10
17秒前
所所应助活力的如冬采纳,获得10
17秒前
虚拟的斑马应助carbonhan采纳,获得10
18秒前
ABS发布了新的文献求助10
18秒前
花道发布了新的文献求助10
19秒前
21秒前
22秒前
22秒前
张三问完成签到,获得积分10
23秒前
24秒前
24秒前
花道完成签到,获得积分10
25秒前
27秒前
YI发布了新的文献求助30
28秒前
aaa应助ZhengSyHoe采纳,获得10
28秒前
金刚经应助Saluzi采纳,获得10
28秒前
星辰大海应助小何采纳,获得10
28秒前
30秒前
11发布了新的文献求助10
31秒前
Shalan完成签到,获得积分10
31秒前
李健的小迷弟应助明眸采纳,获得10
32秒前
YI完成签到,获得积分20
34秒前
劲秉应助忧郁鸣凤采纳,获得10
34秒前
小溜溜完成签到 ,获得积分10
34秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3191125
求助须知:如何正确求助?哪些是违规求助? 2840488
关于积分的说明 8028591
捐赠科研通 2503810
什么是DOI,文献DOI怎么找? 1337205
科研通“疑难数据库(出版商)”最低求助积分说明 638034
邀请新用户注册赠送积分活动 606497