Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction

胎儿 极低密度脂蛋白 胆固醇 内分泌学 内科学 脂类学 脂蛋白 代谢组学 宫内生长受限 脂质代谢 新陈代谢 生物 胎儿生长 化学 生物化学 怀孕 医学 生物信息学 遗传学
作者
Jezid Miranda,Rui V. Simões,Cristina Paulés,Daniel Cañueto,Miguel Ángel Pardo-Cea,Maria Luisa García‐Martín,F. Crovetto,Rocío Fuertes-Martín,Mónica Doménech,María Dolores Gómez‐Roig,E. Eixarch,Ramón Estruch,Stefan R. Hansson,Núria Amigó,Nicolau Cañellas,F. Crispi,E. Gratacós
出处
期刊:Scientific Reports [Springer Nature]
卷期号:8 (1) 被引量:47
标识
DOI:10.1038/s41598-018-31832-5
摘要

Abstract Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
麦乐迪完成签到 ,获得积分10
1秒前
July发布了新的文献求助10
1秒前
1秒前
1秒前
2秒前
劲秉应助格格采纳,获得10
4秒前
斯文败类应助细心的凌香采纳,获得10
4秒前
ws应助科研通管家采纳,获得10
4秒前
酷波er应助科研通管家采纳,获得10
4秒前
5秒前
深情安青应助科研通管家采纳,获得10
5秒前
斯文败类应助科研通管家采纳,获得10
5秒前
5秒前
李爱国应助科研通管家采纳,获得10
5秒前
三叔应助科研通管家采纳,获得10
5秒前
天天快乐应助科研通管家采纳,获得10
5秒前
HEIKU应助科研通管家采纳,获得10
5秒前
CodeCraft应助科研通管家采纳,获得10
5秒前
5秒前
完美世界应助科研通管家采纳,获得10
5秒前
5秒前
5秒前
CipherSage应助科研通管家采纳,获得10
6秒前
Owen应助科研通管家采纳,获得10
6秒前
CipherSage应助科研通管家采纳,获得10
6秒前
无花果应助科研通管家采纳,获得10
6秒前
6秒前
ws应助科研通管家采纳,获得10
6秒前
星辰大海应助科研通管家采纳,获得10
6秒前
6秒前
打打应助科研通管家采纳,获得10
6秒前
爆米花应助科研通管家采纳,获得10
6秒前
7秒前
koitoyu完成签到,获得积分10
7秒前
单薄惜文发布了新的文献求助10
7秒前
hym111完成签到,获得积分10
8秒前
不配.应助畅快白亦采纳,获得10
9秒前
随行发布了新的文献求助10
10秒前
10秒前
从容道天发布了新的文献求助10
12秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188290
求助须知:如何正确求助?哪些是违规求助? 2837794
关于积分的说明 8017206
捐赠科研通 2500478
什么是DOI,文献DOI怎么找? 1334942
科研通“疑难数据库(出版商)”最低求助积分说明 637363
邀请新用户注册赠送积分活动 605381