酵母
商品化学品
烟酰胺腺嘌呤二核苷酸磷酸
化学
生物化学
原材料
糖
磷酸糖
酶
纳米技术
催化作用
材料科学
有机化学
氧化酶试验
作者
Junling Guo,Miguel Suástegui,Kelsey K. Sakimoto,Vanessa M. Moody,Gao Xiao,Daniel G. Nocera,Neel Joshi
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-11-16
卷期号:362 (6416): 813-816
被引量:250
标识
DOI:10.1126/science.aat9777
摘要
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic hybrid platform that consists of highly efficient light-harvesting indium phosphide nanoparticles and genetically engineered Saccharomyces cerevisiae, a workhorse microorganism in biomanufacturing. The yeast harvests photogenerated electrons from the illuminated nanoparticles and uses them for the cytosolic regeneration of redox cofactors. This process enables the decoupling of biosynthesis and cofactor regeneration, facilitating a carbon- and energy-efficient production of the metabolite shikimic acid, a common precursor for several drugs and fine chemicals. Our work provides a platform for the rational design of biohybrids for efficient biomanufacturing processes with higher complexity and functionality.
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