医学
按摩
内科学
入射(几何)
胃肠病学
甲状腺癌
甲状腺
放射性碘疗法
癌症
唾液腺
内分泌学
病理
物理
替代医学
光学
作者
Seung Hyun Son,Changhee Lee,Ji‐hoon Jung,Do-Hoon Kim,Chae Moon Hong,Jae‐Uk Jeong,Shin Young Jeong,Sang‐Woo Lee,Jaetae Lee,Byeong‐Cheol Ahn
出处
期刊:Clinical Nuclear Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2019-05-03
卷期号:44 (8): 625-633
被引量:16
标识
DOI:10.1097/rlu.0000000000002602
摘要
Purpose To evaluate the preventive effect of parotid gland (PG) massage for PG damage during the 131 I therapy, we prospectively investigated the serum amylase value and salivary gland scintigraphy (SGS) after 131 I therapy. Materials and Methods One hundred patients with thyroidectomized differentiated thyroid cancer who underwent high-dose 131 I therapy were enrolled in the clinical trial and randomized into 2 groups (PG massage group and nonmassage group). The serum amylase value was obtained before and 24 hours after 131 I therapy, and the SGSs were also taken just before and at 8 months after the 131 I therapy. Change in serum amylase value and SGS was compared between PG massage and nonmassage groups. Results The difference value of serum amylase was significantly lower in PG massage group than in nonmassage group ( P = 0.0052). Worsening of PG function on SGS was observed in 43 (45.3%) of the 95 patients. The incidence rate of PG abnormality on F/U SGS was significantly lower in PG massage group than in nonmassage group (odds ratio, 0.3704; P = 0.0195). In the multiple regression analysis, PG massage significantly affected the abnormality on the 8-month F/U SGS ( r partial = −0.2741, P = 0.0090) after adjusting for clinical variables (age, sex, TNM stage, TSH preparation methods for the 131 I therapy, and 131 I dose). Conclusions PG gland massage significantly reduced the incidence rates of salivary gland dysfunction on the 8-month F/U SGS and the level of the serological marker of salivary gland destruction after 131 I therapy. Therefore, PG gland massage could alleviate salivary gland damage related to 131 I therapy.
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