The ultrasound characteristics of regions identified as suspicious by magnetic resonance imaging (MRI) predict the likelihood of clinically significant cancer on MRI–ultrasound fusion‐targeted biopsy

医学 磁共振成像 活检 前列腺癌 超声波 放射科 癌症 感兴趣区域 单变量分析 核医学 多元分析 内科学
作者
Benjamin Press,Andrew B. Rosenkrantz,Weiwei Huang,Samir S. Taneja
出处
期刊:BJUI [Wiley]
卷期号:123 (3): 439-446 被引量:8
标识
DOI:10.1111/bju.14615
摘要

Objective To determine whether the presence of an ultrasound hypoechoic region at the site of a region of interest ( ROI ) on magnetic resonance imaging ( MRI ) results in improved prostate cancer ( PC a) detection and predicts clinically significant PC a on MRI –ultrasonography fusion‐targeted prostate biopsy ( MRF ‐ TB ). Materials and Methods Between July 2011 and June 2017, 1058 men who underwent MRF ‐ TB , with or without systematic biopsy, by a single surgeon were prospectively entered into an institutional review board‐approved database. Each MRI ROI was identified and scored for suspicion by a single radiologist, and was prospectively evaluated for presence of a hypoechoic region at the site by the surgeon and graded as 0, 1 or 2, representing none, a poorly demarcated ROI‐HyR, or a well demarcated ROI‐HyR, respectively. The interaction of MRI suspicion score ( mSS ) and ultrasonography grade ( USG ), and the prediction of cancer detection rate by USG , were evaluated through univariate and multivariate analysis. Results For 672 men, the overall and Gleason score ( GS ) ≥7 cancer detection rates were 61.2% and 39.6%, respectively. The cancer detection rates for USG s 0, 1 and 2 were 46.2%, 58.6% and 76.0% ( P < 0.001) for any cancer, and 18.7%, 35.2% and 61.1% ( P < 0.001) for GS ≥7 cancer, respectively. For MRF ‐ TB only, the GS ≥7 cancer detection rates for USG 0, 1 and 2 were 12.8%, 25.7% and 52.0%, respectively ( P < 0.001). On univariate analysis, in men with mSS 2–4, USG was predictive of GS ≥7 cancer detection rate. Multivariable regression analysis showed that USG , prostate‐specific antigen density and mSS were predictive of GS ≥7 PC a on MRF ‐ TB . Conclusions Ultrasonography findings at the site of an MRI ROI independently predict the likelihood of GS ≥7 PC a, as men with a well‐demarcated ROI‐HyR at the time of MRF ‐ TB have a higher risk than men without.
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