Plasma trans-fatty acid and risk of nonalcoholic fatty liver disease: New data from National Health and Nutrition Examination Survey (NHANES)

In this Journal, Mazidi and colleagues published a cross-sectional study investigating the association between liver enzymes, fatty liver index (FLI) and plasma concentrations of relevant trans-fatty acids in a large cohort of US individuals from National Health and Nutrition Examination Survey (NHANES) [ [1] Mazidi M. Katsiki N. Mikhailidis D.P. Banach M. Link between plasma trans-fatty acid and fatty liver is moderated by adiposity. Int. J. Cardiol. 2018; https://doi.org/10.1016/j.ijcard.2018.07.061 Abstract Full Text Full Text PDF PubMed Scopus (14) Google Scholar ]. To date, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease observed in clinical practice, affecting approximately 30–35% of adults in the general population in Western countries [ [2] Younossi Z. Anstee Q.M. Marietti M. Hardy T. Henry L. Eslam M. George J. Bugianesi E. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol. 2018; 15: 11-20 Crossref PubMed Scopus (2439) Google Scholar ]. Notably, it is estimated that NAFLD will be the first underlying etiology for liver transplantation by 2025 in Western countries [ [2] Younossi Z. Anstee Q.M. Marietti M. Hardy T. Henry L. Eslam M. George J. Bugianesi E. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol. 2018; 15: 11-20 Crossref PubMed Scopus (2439) Google Scholar ]. Link between plasma trans-fatty acid and fatty liver is moderated by adiposityInternational Journal of CardiologyVol. 272PreviewThe prevalence of non-alcoholic fatty liver disease (NAFLD) is rising. This increase may be associated with obesity. It has been suggested that trans-fatty acids (TFAs) play an important role in non-communicable diseases. Full-Text PDF