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The determinants of periorbital skin ageing in participants of a melanoma case–control study in the U.K.

医学 老化 晒伤 体质指数 黑色素瘤 皮肤老化 黑素皮质素1受体 皮肤病科 内科学 生物 遗传学 等位基因 癌症研究 基因
作者
Mariano Suppa,Faye Elliott,J Stefoski Mikeljevic,Yosuke Mukasa,May Chan,Susan Leake,Birute Karpavicius,Susan E. Haynes,Egbert Bakker,Ketty Peris,Jennifer H. Barrett,D. Timothy Bishop,Julia Newton‐Bishop
出处
期刊:British Journal of Dermatology [Wiley]
卷期号:165 (5): 1011-1021 被引量:22
标识
DOI:10.1111/j.1365-2133.2011.10536.x
摘要

Skin ageing is said to be caused by multiple factors. The relationship with sun exposure is of particular interest because the detrimental cutaneous effects of the sun may be a strong motivator to sun protection. We report a study of skin ageing in participants of an epidemiological study of melanoma.To determine the predictors of periorbital cutaneous ageing and whether it could be used as an objective marker of sun exposure.Photographs of the periorbital skin in 1341 participants were graded for wrinkles, degree of vascularity and blotchy pigmentation and the resultant data assessed in relation to reported sun exposure, sunscreen use, body mass index (BMI), smoking and the melanocortin 1 receptor (MC1R) gene status. Data were analysed using proportional odds regression.Wrinkling was associated with age and heavy smoking. Use of higher sun-protection factor sunscreen was protective (P = 0·01). Age, male sex, MC1R variants ('r', P=0·01; 'R', P=0·02), higher reported daily sun exposure (P=0·02), increased BMI (P=0·01) and smoking (P=0·02) were risk factors for hypervascularity. Blotchy pigmentation was associated with age, male sex, higher education and higher weekday sun exposure (P=0·03). More frequent sunscreen use (P=0·02) and MC1R variants ('r', P=0·03; 'R', P=0·001) were protective.Periorbital wrinkling is a poor biomarker of reported sun exposure. Vascularity is a better biomarker as is blotchy pigmentation, the latter in darker-skinned individuals. In summary, male sex, sun exposure, smoking, obesity and MC1R variants were associated with measures of cutaneous ageing. Sunscreen use showed some evidence of being protective.
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