Acute Toxicity of Phoxim,Isofenphos-methyl and Acephate to New Zealand Rabbit

Objective To study the acute toxicity of phoxim,isofenphos-methyl and acephate to New Zealand rabbit.Methods The acute toxicity test was carried out in the 150 male and clearing grade New Zealand rabbits,treated with the agents through gavage at 3 ml/kg.The control group(distilled water) and three treatment groups with 5 concentration gradients of phoxim(1.578-2.778 g/kg),isofenphos-methyl(0.011-0.015 g/kg) and acephate(0.052-0.132 g/kg) by the equal difference spacing pattern,respectively.The acute toxic effect characteristics,toxigenicity effect and safe concentration of phoxim,isofenphos-methyl and acephate to New Zealand rabbit were evaluated in the test.Results The half lethal concentrations in 96 h of phoxim,isofenphos-methyl and acephate to New Zealand rabbit were 2.458,0.011 and 0.085 g/kg,respectively.The safe concentrations of phoxim,isofenphos-methyl and acephate to New Zealand rabbit were 0.246,0.001 and 0.009 g/kg,respectively.The acute toxic effect with accumulation was observed,and ranked as isofenphos-methylacephatephoxim.Conclusion Phoxim is considered as the low-toxic phosphate pesticide,acephate as the moderate-toxic phosphate pesticide and isofenphos-methyl as the high-toxic phosphate pesticide to New Zealand rabbit.