Enantio Selective Synthesis of Chairal Alfa Amino Acids by Phase Transfer Catalysts

化学 催化作用 甘氨酸 氨基酸 烷基化 有机化学 基础(拓扑) 肽合成 生物化学 数学 数学分析
作者
Haniyeh Alavi,Mehdi Daryani
出处
期刊:Oriental journal of chemistry [Oriental Scientific Publishing Company]
卷期号:29 (1): 135-143 被引量:2
标识
DOI:10.13005/ojc/290124
摘要

Amino Acids are consider as main base units forming peptide & Protein’s composites. They‘re playing important role in defining and forming or making them (Amino Acids) artificially in chemical labs. In this research, converting Glycine Amino Acid (without Chiral Carbon) to desirable Amino acids through proper Calkylation’s process in salty chemical environment with present of phase transfer catalyst. With the present of Glycine as well as alkyl agent in Organic phase & base in water Phase and a Phase transfer catalyst forming Mono anion at phase as a mono alkylation Glycine product controlled production. As mentioned the aim of this research is the chiral amino acids synthesis. Glycine Amino acid is Chosen as a base abundant material in nature. Then every artificial compositions purified. Following compositions has recrystallization with petroleum ether and formed the production through chromatogram of (TLC), then detecting by comparing their RF with other composition’s RF to prove & support the production’s purifications grade. And then for final result, in order to define clearly and completely, 1H-NMR and other methods such as IR & Mass spectrums measuring we have been used. Achieved results from composed productions shows, their formations and performance is depended on proper composition periods (speed). s ed om composed es has been used
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