米诺环素
CCR2型
神经病理性疼痛
小胶质细胞
医学
体内
坐骨神经
敌手
刺激
药理学
炎症
麻醉
内科学
趋化因子
受体
化学
生物
趋化因子受体
抗生素
生物技术
生物化学
作者
Anna Piotrowska,Klaudia Kwiatkowski,Ewelina Rojewska,Joanna Ślusarczyk,Wioletta Makuch,Agnieszka Basta‐Kaim,Barbara Przewłocka,Joanna Mika
标识
DOI:10.1016/j.jneuroim.2016.04.017
摘要
The repeated administration of microglial inhibitor (minocycline) and CCR2 antagonist (RS504393) attenuated the neuropathic pain symptoms in rats following chronic constriction injury of the sciatic nerve, which was associated with decreased spinal microglia activation and the protein level of CCL2 and CCR2. Furthermore, in microglia primary cell cultures minocycline downregulated both CCL2 and CCR2 protein levels after lipopolysaccharide-stimulation. Additionally, in astroglia primary cell cultures minocycline decreased the expression of CCL2, but not CCR2. Our results provide new evidence that modulation of CCL2/CCR2 pathway by microglial inhibitor as well as CCR2 antagonist is effective for neuropathic pain development in rats.
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