Sesquiterpenoids from Curcuma wenyujin dreg and their biological activities

Four new sesquiterpenoids, 4,8-dioxo-6β-hydroxyl-7β,11-epoxycarabrane (1), 4,8-dioxo-6β-hydroxyl-7α,11-epoxycarabrane (2), wenyujinins Q and R (3–4), and nine known sesquiterpenoids (5–13) were isolated from the Curcuma wenyujin (C. wenyujin) dreg. Their structures and relative configurations were elucidated using 1D, 2D NMR, and HR-ESI-MS data. All the compounds were isolated for the first time from the C. wenyujin dreg and evaluated for their antibacterial and antifungal activities. Compounds 3, 5–8 exhibited strong broad-spectrum antifungal activities against tested nine pathogenic fungi.