石蒜碱
石蒜科
丁酰胆碱酯酶
生物碱
化学
胆碱酯酶
石蒜科生物碱
乙酰胆碱酯酶
色谱法
气相色谱-质谱法
水仙
阿切
立体化学
植物
药理学
生物化学
酶
生物
质谱法
作者
Lucie Cahlíková,Kateřina Macáková,Stanislav Zavadil,Pavel Jiroš,Lubomı́r Opletal,Klára Urbanová,Luděk Jahodář
标识
DOI:10.1177/1934578x1100600506
摘要
The underivatized alkaloid mixture extracted from the bulbs of Chlidanthus fragrans Herb. was investigated by capillary GC/MS for the first time. Fifteen known Amaryllidaceae alkaloids of five structure types were identified. The main alkaloids were tazzetine (9, tazettine-type), chlidanthine (2, galanthamine-type), belladine (8, belladine-type) and lycorine (12, lycorine-type). The alkaloid extract from the bulbs showed promising human blood acetylcholinesterase (IC 50 = 20.1 ± 2.9 μg/mL) and human plasma butyrylcholinesterase (IC 50 = 136.8 ± 6.9 μg/mL) inhibitory activity.
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