环糊精
壳聚糖
化学
Zeta电位
β-环糊精
包合物
化学计量学
核化学
纳米颗粒
纳米技术
色谱法
有机化学
材料科学
作者
Peixiao Tang,Hongqin Yang,Bin Tang,Di Wu,Qiaohong Du,Kailin Xu,Hui Li
标识
DOI:10.1016/j.carbpol.2016.09.038
摘要
This study aimed to investigate a novel delivery system for salazosulfapyridine (SASP) through encapsulation in 2,6-dimethyl-β-cyclodextrin (DMβCD) and further incorporation in chitosan (CS) to form nanoparticles (NPs). The inclusion complex of SASP and DMβCD was prepared at 1:1 host-guest stoichiometry based on Job's plot and then characterized through various analytical techniques. Then, the DMβCD/SASP inclusion complex was incorporated in CS to form DMβCD/SASP/CS NPs. The loading efficiency of SASP in the DMβCD/SASP/CS NPs was significantly higher than that of the SASP/CS NPs. A positive zeta potential of +35.4mV was also observed in the DMβCD/SASP/CS NPs with an average size of 90nm. SASP exhibited a sustained release after the DMβCD/SASP/CS NPs were formed. The toxicity of the NPs to LO2 cells was lower than that of free SASP. Therefore, the CD inclusion complex-loaded CS NPs can be applied to deliver hydrophobic drugs.
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