常染色体显性多囊肾病
包装D1
医学
疾病
Copeptin蛋白
内科学
肾功能
多囊肾病
肿瘤科
肾脏疾病
病理
泌尿科
加压素
作者
Corradi,Fiorella Gastaldon,Carlotta Caprara,Anna Giuliani,Francesca Martino,Fiorenza Ferrari,Claudio Ronco
出处
期刊:Minerva Medica
[Edizioni Minerva Medica]
日期:2017-02-01
卷期号:108 (1)
被引量:6
标识
DOI:10.23736/s0026-4806.16.04830-8
摘要
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic diseases with a reported prevalence of 1:400 to 1:1000. Since the intact kidneys can compensate for the loss of glomerular filtration in ADPKD patients, renal insufficiency usually remains undetected until almost the fourth decade of life. Hereafter, reliable diagnostic and prognostic biomarkers to identify ADPKD progression are urgently needed. Several studies and systematic reviews tried to identify markers or predictors of rapid disease progression of ADPKD. The aim of this study is to review predictors of rapid disease progression of ADPKD that can be useful to the clinician. We will describe several factors associated with rapid progression of ADPKD derived from retrospective or cross-sectional studies, suggesting the best and most useful predictors that may help to patients management in clinical practice. We will attempt to identify the most useful predictors of rapid disease progression of ADPKD: established TKV growth rate >5% per year, annual estimated glomerular filtration rate decline >5 mL/min/1.73 m2, truncating PKD1 mutations and elevated plasma copeptin level. The combination of several factors that can predict the rapid ADPKD progression is more accurate than a single-marker strategy. The "PRO-PKD" risk scoring system combined with TKV, can be useful in order to evaluate the ADPKD patients and they appear to be appropriate predictors of progression disease. Moreover levels of copeptin and some urinary markers can be matched to these factors for improved patient assessment in rapid progression.
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