Solvent‐Free Buchwald–Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

Abstract A highly efficient solvent‐free protocol for the Buchwald–Hartwig amination of (hetero)aryl halides by secondary amines was developed. The reaction is mediated by a Pd(OAc) 2 /RuPhos catalytic system in air. Various (hetero)aryl halides were coupled with diaryl, alkyl–aryl, and dialkylamines in good to excellent yields (51 examples, 50–99 % yield).