The photocage is a light sensitive substance for photo-controlled release, which is formed by combining the target substance with photosensitive group and other functional groups through physical and chemical methods.Under the irradiation of the specified band, the photocage releases the target substance.It is widely concerned because it can realize space-time control, which means that the time and place of release are controllable.The advantages of simple operation, easy control, strong modification ability and small body damage make it widely used in chemistry, biology, materials science and medicine.In this paper, we introduced and discussed the research progress of photocages in photo-controlled release of metal ions, gases, fluorescent substances, amino acids, peptides, enzymes, proteins, drugs and other target substances in recent 10 years.