A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice

The anti-obesity mechanism of SCF. The anti-obesity effects of SCF were possibly due to the following: (1) SCF improves lipid metabolism via adiponectin receptor/AMPK signalling; and (2) SCF modulates gut microbiota and production of SCFAs in mice.