胶体金
表面等离子共振
材料科学
共轭体系
钴
抗坏血酸
连接器
纳米颗粒
纳米技术
核化学
化学
聚合物
复合材料
冶金
操作系统
计算机科学
食品科学
作者
A’Lester C. Allen,Mekedlawit Efrem,M. Umadevi,Melissa Guarino‐Hotz,Alejandro R. Foley,Jevgenij A. Raskatov,Chengyu Song,Sarah A. Lindley,Jing Li,Bin Chen,Jin Z. Zhang
标识
DOI:10.1021/acs.jpcb.1c06776
摘要
Hollow gold nanospheres (HGNs) have been used as the template for seed-mediated growth of multibranched hollow gold nanostars (HNS). The HGNs were synthesized via anerobic reduction of cobalt chloride to cobalt nanoparticles and then formation of a gold shell via galvanic replacement followed by the oxidation of the cobalt core. We obtained control of the inner core size of the HGNs by increasing the size of the sacrificial cobalt core and by varying the ratio of B(OH)3/BH4 using boric acid rather than 48 h aged borohydride. We synthesized the HNS by reducing Au3+ ions in the presence of Ag+ ions using ascorbic acid, creating a spiky morphology that varied with the Au3+/Ag+ ratio. A broadly tunable localized surface plasmon resonance was achieved through control of both the inner core and the spike length. Amyloid beta (Aβ) was conjugated to the HNS by using a heterobifunctional PEG linker and identified by the vibrational modes associated with the conjugated ring phenylalanine side chain. A bicinchoninic acid assay was used to determine the concentration of Aβ conjugated to HNS as 20 nM, which is below the level of Aβ that negatively affects long-term potentiation. Both the core size and spike length were shown to affect the optical properties of the resulting nanostructures. This HGN templated method introduced a new parameter for enhancing the plasmonic properties of gold nanostars, namely, the addition of a hollow core. Hollow gold nanostars are highly desirable for a wide range of applications, including high sensitivity disease detection and monitoring.
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