Objective: To analyze the clinical effect of fiberoptic bronchoscopy in treating severe ventilator-associated pneumonia (VAP). Methods: From September 2018 to October 2019, 100 patients with severe VAP were recruited as the study cohort and randomly divided into two groups, with 50 patients in each group. The control group underwent routine treatment, such as lavage, and the experimental group underwent fiberoptic bronchoscopy. The effectiveness rates, recovery times, and respiratory mechanics indexes of the two groups were compared. Result: The total effective rate of the clinical treatment in the experimental group was significantly higher than it was in the control group (P < 0.05), and the recovery time in the experimental group was significantly shorter than it was in the control group (P < 0.05). After the treatment, the experimental group was significantly better than the control group (P < 0.05). After the treatment, the IL-8, CRP, and PCT levels in the experimental group were significantly lower than they were in the control group (P < 0.05). Conclusion: Fiberoptic bronchoscopy can significantly improve the therapeutic effect of VAP, significantly shorten patients’ recovery times, significantly improve the respiratory mechanics-related indicators, and improve the therapeutic effect, so it is worthy of promotion.