夜蛾科
藤黄属
化学
立体化学
阳性对照
细胞毒性T细胞
IC50型
传统医学
细胞毒性
光谱分析
MTT法
体外
生物化学
医学
光谱学
物理
量子力学
作者
Nguyễn Thị Thu Hà,Nguyễn Văn Tuyên,Nguyen Thanh Tra,Le Thị Tu Anh,Ninh The Son,Mac Litaudon,Phạm Văn Cường,Bùi Hữu Tài,Phan Văn Kiệm
标识
DOI:10.1080/14786419.2021.1950717
摘要
Three new xanthones, garcimckeans A-C (1-3) were isolated from the methanol extract of the stems of Garcinia mckeaniana (Clusiaceae). Their structures were established by extensive spectroscopic analysis (HR-ESI-MS and 1 D and 2 D NMR) and by comparison of the spectral data with those reported in the literature. Compounds 1-3 displayed weak cytotoxic activity toward KB, Lu, HepG2, and MCF7 cell lines using the MTT assay with IC50 values ranging from 71.03 ± 2.93 to 90.40 ± 7.13 µM compared to that of the positive control compound, ellipticine (IC50: 1.22 ± 0.10 ∼ 2.44 ± 0.2 µM).
科研通智能强力驱动
Strongly Powered by AbleSci AI