生物
神经管
脊髓
神经细胞
神经科学
胚胎干细胞
祖细胞
感觉系统
转录组
神经干细胞
解剖
基因表达谱
胚胎
神经发育
GDF7型
神经嵴
电池类型
细胞生物学
基因
细胞
基因表达
遗传学
干细胞
作者
Teresa Rayón,Rory J. Maizels,Christopher Barrington,James Briscoe
出处
期刊:Development
[The Company of Biologists]
日期:2021-07-16
卷期号:148 (15)
被引量:95
摘要
ABSTRACT The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are carried out by neural circuits comprising molecularly distinct neuronal subtypes generated in a characteristic spatiotemporal arrangement from progenitors in the embryonic neural tube. To gain insight into the diversity and complexity of cells in the developing human neural tube, we used single-cell mRNA sequencing to profile cervical and thoracic regions in four human embryos of Carnegie stages (CS) CS12, CS14, CS17 and CS19 from gestational weeks 4-7. Analysis of progenitor and neuronal populations from the neural tube and dorsal root ganglia identified dozens of distinct cell types and facilitated the reconstruction of the differentiation pathways of specific neuronal subtypes. Comparison with mouse revealed overall similarity of mammalian neural tube development while highlighting some human-specific features. These data provide a catalogue of gene expression and cell type identity in the human neural tube that will support future studies of sensory and motor control systems. The data can be explored at https://shiny.crick.ac.uk/scviewer/neuraltube/.
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