青鳉属
维甲酸
维甲酸受体
毒性
发育毒性
人口
受体
胚胎
内科学
内分泌学
急性毒性
男科
胚胎发生
视黄醇X受体
细胞生物学
生物化学
生物
胎儿
遗传学
怀孕
细胞培养
医学
核受体
基因
环境卫生
转录因子
作者
Yu Li,Haojia Ma,Ruichao Chen,Hong Zhang,Tsuyoshi Nakanishi,Jianying Hu
标识
DOI:10.1021/acs.est.0c06809
摘要
2-Ethylhexyl diphenyl phosphate (EHDPP) has been detected in wild fish with high concentrations, which may pose a risk in the embryo development considering its potential maternal transfer. In this study, EHDPP was demonstrated to elicit antagonistic activity to medaka retinoic acid receptor (mRAR) and retinoic X receptor (mRXR) with 50% inhibitory concentration of 18 and 36 μM, respectively. After adult female medaka were exposed to EHDPP at 156, 405, and 1161 ng/L for 35 days, the embryonic EHDPP concentrations (364–4824 ng/g lipid weight (lw)) were higher than those in the maternal tissues (15.0–4166 ng/g lw), showing notable maternal transfer. The embryonic concentration of EHDPP decreased limitedly during 1-2 day post-fertilization (dpf, the main developmental window of eye) but then decreased sharply after 2 dpf. The transcript abundance of cyp26a1 was inhibited and subsequent increasing embryonic all-trans RA level was observed in embryos, showing RAR/RXR antagonistic activity. These results may specifically contribute to the increased eye deformity incidences in all exposure groups (up to 8.0%; 51/637) relative to the control (1.0%, 7/733). The response behavior of the larvae to light stimulation was impaired in a dose-dependent manner, demonstrating a vision disorder. Because such developmental toxicities were observed at the environmental level, EHDPP may pose a threat to the survival of wild larvae and therefore a population risk for wild fish.
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