Dynamic 18F-FDG Total Body PET Imaging as a Predictive Marker of Induction Chemo-Immunotherapy Followed by Concurrent Chemoradiotherapy Response in Locally Advanced Non-Small Cell Lung Cancer

医学 肺癌 核医学 放化疗 淋巴结 内科学 标准摄取值 正电子发射断层摄影术 前瞻性队列研究 肿瘤科 放射科
作者
Huanliang Liu,B. Qiu,Dawei Wang,Xiang Zhang,Ying Zhou,Qunxing Li,Chu Chu,FangJie Liu,NaiBin Chen,Nan Hu,Xin-Lei Ai,JinYu Guo,Wei Fan
出处
期刊:International Journal of Radiation Oncology Biology Physics [Elsevier BV]
卷期号:111 (3): e445-e445
标识
DOI:10.1016/j.ijrobp.2021.07.1257
摘要

Purpose/Objective(s)

The purpose of this study was to evaluate the efficacy of dynamic 18F-FDG total body PET imaging as a predictive maker of induction chemo-immunotherapy followed by concurrent chemoradiotherapy (CCRT) response in locally advanced non-small cell lung cancer (LA-NSCLC) by a prospective study.

Materials/Methods

Stage IIIA-IIIC NSCLC patients were prospectively enrolled in a prospective total body PETCT study (NCT04654234, GASTO-1067) and a randomized phase II clinical trial (NCT04085250) between September 2020 and December 2020. Patients underwent a dynamic total-body 18F-FDG PET/CT scan before any treatment, after 2 cycles of induction chemo-immunotherapy (docetaxel + cisplatin + nivolumab), then after CCRT. The primary lung tumor, metastatic regional lymph node and inflammatory lymph node before and after treatment were manually delineated by a nuclear medicine physician and a radiation oncologist. Total Body PET was acquired between 0 – 60 mins after the injection of FDG from the subject's feet. Patients was separated into high dynamic FDG metabolic (H-DFM) group and low DFM(L-DFM) group by the scatter plot of SUV-mean and Ki-mean of baseline scan for primary lung tumor. We compared lesion heterogeneity and different image-derived PET metrics including the metabolic tumor volume (MTV), SUV total lesion glycolysis (SUV-TLG), Patlak-derived influx rate constant (Ki) TLG (Ki-TLG).

Results

Fifteen patients completed three scans (before treatment, after induction chemo-immunotherapy, after CCRT). Eight patients were in H-DFM group and 7 in L-DFM group by baseline scan. Patients in H-DFM group had significant decreased levels of MTV (P < 0.001), SUV-TLG (P < 0.001) and Ki-TLG (P < 0.001) both in primary lung tumor and metastatic lymph node by the induction chemo-immunotherapy and CCRT. However, patients in L-DFM group only had a significant reduction of MTV in primary lung tumor (P < 0.05). There was no significant difference in the MTV of metastatic lymph node (P > 0.5), the SUV-TLG (P > 0.5) and Ki-TLG (P > 0.5) of primary lung tumor and metastatic lymph node during the treatment course in L-DFM group.

Conclusion

Patients in H-DFM group had the better treatment response of induction chemo-immunotherapy and CCRT with significant decreased levels of MTV, SUV-TLG and Ki-TLG. Dynamic 18F-FDG Total body PET Imaging could be regarded as a potential predictive marker of induction chemo-immunotherapy and CCRT response in the setting of LA-NSCLC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Tethys发布了新的文献求助10
刚刚
传奇3应助唐Doctor采纳,获得10
2秒前
纳斯达克发布了新的文献求助10
2秒前
3秒前
善学以致用应助dongdong采纳,获得10
3秒前
5秒前
5秒前
6秒前
安然发布了新的文献求助20
6秒前
科研通AI5应助Cici采纳,获得10
6秒前
8秒前
9秒前
hyc发布了新的文献求助10
10秒前
genuine发布了新的文献求助10
10秒前
10秒前
斯文败类应助药毛儿采纳,获得10
12秒前
沐晴发布了新的文献求助10
12秒前
科研栀完成签到,获得积分10
12秒前
1WSQARFGRDSX发布了新的文献求助10
12秒前
CipherSage应助ark861023采纳,获得10
13秒前
13秒前
13秒前
闪闪落雁完成签到,获得积分10
13秒前
14秒前
14秒前
Onism发布了新的文献求助10
15秒前
sciiiiii发布了新的文献求助10
16秒前
vv123456ha发布了新的文献求助10
17秒前
18秒前
吧唧一笑的go完成签到,获得积分10
18秒前
Shapee完成签到,获得积分10
18秒前
orixero应助boltos采纳,获得10
18秒前
19秒前
20秒前
多多发布了新的文献求助10
22秒前
852应助liuzengzhang666采纳,获得10
22秒前
Onism完成签到,获得积分10
24秒前
李爱国应助平常的紫蓝采纳,获得10
25秒前
药毛儿发布了新的文献求助10
25秒前
彭于晏应助menghongmei采纳,获得10
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988827
求助须知:如何正确求助?哪些是违规求助? 3531197
关于积分的说明 11252739
捐赠科研通 3269830
什么是DOI,文献DOI怎么找? 1804815
邀请新用户注册赠送积分活动 881915
科研通“疑难数据库(出版商)”最低求助积分说明 809028